Inhibition of TWEAK/Fn14 Ameliorates Sarcopenic Obesity by Restoring Mitochondrial Biogenesis via the AMPK/SIRT1/PGC-1α Axis
Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Yanying Guo, Shuke Guo, Qihong Xu, Jiayu Ke, Lei Xu, Yining Yang, Hongmei Wang · 2026
Read Inhibition of TWEAK/Fn14 Ameliorates Sarcopenic Obesity by Restoring Mitochondrial Biogenesis via the AMPK/SIRT1/PGC-1α Axis by Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Yanying Guo, Shuke Guo, Qihong Xu, Jiayu Ke, Lei Xu, Yining Yang, Hongmei Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13196728.txt.
Description
Xuekelati and co-authors show that silencing a muscle-wasting signal reverses sarcopenic obesity in mice, in a 2026 study. The condition pairs shrinking muscle with excess fat in older adults. The signal, TWEAK acting through its receptor Fn14, was blocked in the muscles of aged mice fed a fatty diet, and in fat-stressed muscle cells in dishes.
Treated mice gripped harder, carried less fat, and showed lower inflammation and blood lipids. Their muscle cells made more energy and less damaging oxygen waste, as a key energy pathway switched back on and rebuilt the cells' power plants. The authors nominate the pathway as a drug target for age-related decline.
Catalog record
| CREATOR | Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Yanying Guo, Shuke Guo, Qihong Xu, Jiayu Ke, Lei Xu, Yining Yang, Hongmei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |