Functional characterisation of dura mater αCGRP degradation fragments at vascular, immune, and CGRP receptor targets
Mette N. Jensen, Jens B. Kristensen, Maria Castrillo, Philip V. Reducha, Karin M. L. Nordahl, Debbie L. Hay, Kristian A. Haanes · 2026
Read Functional characterisation of dura mater αCGRP degradation fragments at vascular, immune, and CGRP receptor targets by Mette N. Jensen, Jens B. Kristensen, Maria Castrillo, Philip V. Reducha, Karin M. L. Nordahl, Debbie L. Hay, Kristian A. Haanes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13196087.txt.
Description
Mette Jensen and co-authors test what happens to a migraine linked peptide as it breaks down in the membrane around the brain. Their 2026 study deals with CGRP, a messenger that can trigger migraine attacks. Drugs against it help many patients, but responses vary. Local breakdown in the tissue may shape how much active peptide remains. Protein scans found the fragments the peptide splits into in rat membrane samples.
The full peptide vanished fast in that setting and changed the membrane's electrical resistance. Seven fragments made up about 81.5 percent of the fragment pool. None of them activated the peptide's receptor. None changed membrane resistance or immune cell release either. In artery tests they were likewise inert, bar one partial fragment with weak activity. The team also checked whether fragments disturb the standard test for the peptide.
Catalog record
| CREATOR | Mette N. Jensen, Jens B. Kristensen, Maria Castrillo, Philip V. Reducha, Karin M. L. Nordahl, Debbie L. Hay, Kristian A. Haanes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |