GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening
Hannes Schihada, Aida Shahraki, Ainoleena Turku-Metsänen, Maximilian Rath, Lukas Wirth, Katarina Nemec, Hrisowalantu Tselepli, Laura Heitzer, Bernadette Vallaster, Mariam Fadel, Gunnar Schulte, Daniel Hilger, Steffen Pockes, Martin J. Lohse, Peter Kolb · 2026
Read GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening by Hannes Schihada, Aida Shahraki, Ainoleena Turku-Metsänen, Maximilian Rath, Lukas Wirth, Katarina Nemec, Hrisowalantu Tselepli, Laura Heitzer, Bernadette Vallaster, Mariam Fadel, Gunnar Schulte, Daniel Hilger, Steffen Pockes, Martin J. Lohse, Peter Kolb (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13195669.txt.
Description
Hannes Schihada and co-authors report a 2026 drug hunt for a receptor called GPR3, which lacks good drug-like binders. The receptor plays roles in fat cell energy use and in Alzheimer's disease, so both boosters and blockers could help. Standard screens read downstream signals and had failed to find strong leads.
The team built a sensor that watches the receptor change shape in living cells. They paired it with computer screening against model forms of the receptor and classic chemistry work. The hunt found new binders, one of which steers the receptor's signal at very low doses. The sensor plan may also crack other hard receptors that lack known partners. Fresh GPR3 leads now await tuning into drug candidates.
Catalog record
| CREATOR | Hannes Schihada, Aida Shahraki, Ainoleena Turku-Metsänen, Maximilian Rath, Lukas Wirth, Katarina Nemec, Hrisowalantu Tselepli, Laura Heitzer, Bernadette Vallaster, Mariam Fadel, Gunnar Schulte, Daniel Hilger, Steffen Pockes, Martin J. Lohse, Peter Kolb |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |