Time-Resolved Native Mass Spectrometry for Direct Measurement of Biomolecular Kinetics
Virginia K. James, Lauren Stover, Hanieh Bahramimoghaddam, Tanishq Khandelwal, Jing-Yuan Chang, James Downing, Elena Scott, Kathleen O. Bailey, David H. Russell, Lane A. Baker, Arthur Laganowsky · 2026
Read Time-Resolved Native Mass Spectrometry for Direct Measurement of Biomolecular Kinetics by Virginia K. James, Lauren Stover, Hanieh Bahramimoghaddam, Tanishq Khandelwal, Jing-Yuan Chang, James Downing, Elena Scott, Kathleen O. Bailey, David H. Russell, Lane A. Baker, Arthur Laganowsky (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13195665.txt.
Description
Virginia James and co-authors present a method that watches proteins bind and unbind in real time, using a mass spectrometer, in a 2026 paper. How fast partners join and part drives drug action and cell control. Yet standard tools need one partner fixed to a surface or tagged with a label, and they measure binding only indirectly.
The new approach weighs whole complexes as they form and break apart in free solution, with no labels and no fixing. It needs only tiny amounts of sample and returns speeds within minutes. On well-studied test pairs, its numbers matched those from a standard surface tool. The team also timed a protein binding a small drug-like molecule, including one that locks on for good. They offer the method as a direct window on binding for drug research.
Catalog record
| CREATOR | Virginia K. James, Lauren Stover, Hanieh Bahramimoghaddam, Tanishq Khandelwal, Jing-Yuan Chang, James Downing, Elena Scott, Kathleen O. Bailey, David H. Russell, Lane A. Baker, Arthur Laganowsky |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |