Integrating Polygenic Risk and Ocular Phenotyping Reveals an Axial-Length–Dominant Mechanism in High and Extreme High Myopia
Jingwen Hui, Xuehao Cui, Qiuchen Zhao, Liyu Ren, Ying Wang, Xiaoyan Yang, Jing Wang, Quanhong Han · 2026
Read Integrating Polygenic Risk and Ocular Phenotyping Reveals an Axial-Length–Dominant Mechanism in High and Extreme High Myopia by Jingwen Hui, Xuehao Cui, Qiuchen Zhao, Liyu Ren, Ying Wang, Xiaoyan Yang, Jing Wang, Quanhong Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13195619.txt.
Description
ObjectiveTo integrate polygenic risk scoring with detailed ocular phenotyping to investigate severity-related genetic architecture in high myopia (HM) and extreme HM (EHM) in a clinically deeply phenotyped Chinese cohort.DesignHospital-based cross-sectional genetic association study.ParticipantsA total of 576 participants from Tianjin Eye Hospital were included, comprising 443 individuals with myopia, 105 with HM, and 28 with EHM.
Catalog record
| CREATOR | Jingwen Hui, Xuehao Cui, Qiuchen Zhao, Liyu Ren, Ying Wang, Xiaoyan Yang, Jing Wang, Quanhong Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |