Location and organization of a complex, integrated transgenic array in a Caenorhabditis elegans strain carrying hlh-29p::gfp
Simon Anderson, Karen Barnard-Kubow, Casonya Johnson · 2026
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Description
A worm strain used in development research glows green wherever a certain gene is on, thanks to an inserted array of extra DNA. Simon Anderson, Karen Barnard-Kubow, and Casonya Johnson used long-read sequencing to find out exactly where that array sits in the genome of the roundworm Caenorhabditis elegans and how it is put together. The gene in question belongs to a family that guides animal development and features in human disease.
The array turned out to be at least 188.5 thousand bases long, lodged in chromosome III. It carries at least 26 copies of the glowing reporter construct and 11 copies of a second marker gene. Two nearby coding sequences were deleted when the array inserted, though the worms show no visible problems from the loss. The authors present the map as a reference for anyone using the strain.
Catalog record
| CREATOR | Simon Anderson, Karen Barnard-Kubow, Casonya Johnson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |