Fpr1p mediates the synergistic effect of rapamycin or tacrolimus with caspofungin in Clavispora lusitaniae in vitro
Maxime Lefranc, Isabelle Accoceberry, Valérie Fitton-Ouhabi, Nicolas Biteau, Thierry Noël · 2026
Read Fpr1p mediates the synergistic effect of rapamycin or tacrolimus with caspofungin in Clavispora lusitaniae in vitro by Maxime Lefranc, Isabelle Accoceberry, Valérie Fitton-Ouhabi, Nicolas Biteau, Thierry Noël (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13195513.txt.
Description
Maxime Lefranc and four co-authors study drug teamwork against a yeast in a paper dated 2026. The antifungal caspofungin attacks the yeast's cell wall. Two immune-suppressing drugs share a cell receptor, and earlier hints said they might boost the antifungal.
Using checkerboard tests in liquid culture, the team measured how pairs of drugs performed against a wild yeast strain and strains built to lack or overflow the shared receptor. Teamwork appeared in the wild strain across all pairings and both scoring methods. Deleting the receptor gene erased most of the boost, marking the receptor as the mediator. A faint effect without the receptor hints at a backup path. Such pairings could matter as fungal resistance grows.
Catalog record
| CREATOR | Maxime Lefranc, Isabelle Accoceberry, Valérie Fitton-Ouhabi, Nicolas Biteau, Thierry Noël |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |