The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention
Getasew Shitaye, Martina Dragone, Zewdie Mekonnen, Awet Ghebretinsae Tewelde, Maria Della Valle, Gaetano Caputo, Mohammadhossein Mosalaeizadehyazd, Gianluca D'Abrosca, Luigi Russo, Roberto Fattorusso, Carla Isernia, Gaetano Malgieri · 2026
Read The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention by Getasew Shitaye, Martina Dragone, Zewdie Mekonnen, Awet Ghebretinsae Tewelde, Maria Della Valle, Gaetano Caputo, Mohammadhossein Mosalaeizadehyazd, Gianluca D'Abrosca, Luigi Russo, Roberto Fattorusso, Carla Isernia, Gaetano Malgieri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13195429.txt.
Description
Getasew Shitaye leads a 2026 review of the protein corona, the layer of proteins that coats tiny particles entering the body. A particle's biological identity is set not by its bare surface but by this corona, which forms from the fluids around it. The corona remains a major challenge for nanomedicine, medicine at the tiny scale.
The review explains how particle traits and the body environment shape corona formation. It then argues the field urgently needs standard, high-resolution methods. Standard methods would let results be compared and reproduced across labs. The review also explores untapped potential. Such particles can speed or slow the protein clumping behind brain diseases. The corona itself shapes that process, opening intervention ideas.
Catalog record
| CREATOR | Getasew Shitaye, Martina Dragone, Zewdie Mekonnen, Awet Ghebretinsae Tewelde, Maria Della Valle, Gaetano Caputo, Mohammadhossein Mosalaeizadehyazd, Gianluca D'Abrosca, Luigi Russo, Roberto Fattorusso, Carla Isernia, Gaetano Malgieri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |