Evaluation of three variants of the carbapenem inactivation method for carbapenemase detection in Enterobacterales and description of the cCIM, supplemented with cloxacillin
Julia Abels, Jessica Eisfeld, Jennifer Pienkoß, Sören G Gatermann, Niels Pfennigwerth · 2026
Read Evaluation of three variants of the carbapenem inactivation method for carbapenemase detection in Enterobacterales and description of the cCIM, supplemented with cloxacillin by Julia Abels, Jessica Eisfeld, Jennifer Pienkoß, Sören G Gatermann, Niels Pfennigwerth (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13195027.txt.
Description
Julia Abels is first author on a 2026 evaluation of three lab tests for detecting carbapenemase enzymes in gut bacteria. These enzymes break carbapenem antibiotics, last-line drugs, and infections with producing bacteria carry high death rates and costs. Quick, reliable detection guides treatment and infection control, but some tests give false positives in bacteria that overproduce a related enzyme.
Each variant was run on one hundred and ninety-nine isolates reflecting German hospital strains. The zinc-supplemented version performed best overall, catching every producer. A new cloxacillin-supplemented version was most accurate at ruling out non-producers, especially in the tricky related-enzyme group, though it missed a few more producers. Test choice, the authors imply, depends on the local problem.
Catalog record
| CREATOR | Julia Abels, Jessica Eisfeld, Jennifer Pienkoß, Sören G Gatermann, Niels Pfennigwerth |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |