CTMP-REV7 axis modulates MHC-I antigen presentation via CDK1-AKT crosstalk in MSI-L/MSS colorectal cancer
Cheng Gu, Rong He, Xiaolan Yin, Jie Wang, Jing Yang, Jie Gao, Rongjia Xie, Yangyang Geng, Jingyi Lu, Zhui Ke, Zhuqing Liu, Qing Xu · 2026
Read CTMP-REV7 axis modulates MHC-I antigen presentation via CDK1-AKT crosstalk in MSI-L/MSS colorectal cancer by Cheng Gu, Rong He, Xiaolan Yin, Jie Wang, Jing Yang, Jie Gao, Rongjia Xie, Yangyang Geng, Jingyi Lu, Zhui Ke, Zhuqing Liu, Qing Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194846.txt.
Description
Cheng Gu and eleven co-authors study why some bowel cancers hide from the immune system, in a research paper from 2026. These cancers have few mutations, so immune drugs often fail against them. A protein called CTMP may help the tumor stay hidden and reshape its energy use.
Lab and mouse work shows CTMP partners with another protein, REV7, to lower a key display molecule that flags cancer for immune attack. High CTMP went with shorter survival in patients. Blocking the CTMP path in mice slowed tumors and let more killer T cells in. The authors say this axis could be a drug target for these hard-to-treat cancers.
Catalog record
| CREATOR | Cheng Gu, Rong He, Xiaolan Yin, Jie Wang, Jing Yang, Jie Gao, Rongjia Xie, Yangyang Geng, Jingyi Lu, Zhui Ke, Zhuqing Liu, Qing Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |