Noninvasive detection and prognostic stratification of biliary tract cancer using cell-free DNA fragmentomics: a model development and validation study
Jiwen Wang, Xiaojian Ni, Yuxuan Zheng, Song Wang, Hua Bao, Kun Fan, Sheng Shen, Dongqin Zhu, Qingxin Xie, Hairong Bao, Ruowei Yang, Chunyan Wang, Bohao Zheng, Shuang Chang, Xiuxiu Xu, Xiaoling Ni, Tao Suo, Xue Wu, Han Liu, Xiaokun Ma, Houbao Liu · 2026
Read Noninvasive detection and prognostic stratification of biliary tract cancer using cell-free DNA fragmentomics: a model development and validation study by Jiwen Wang, Xiaojian Ni, Yuxuan Zheng, Song Wang, Hua Bao, Kun Fan, Sheng Shen, Dongqin Zhu, Qingxin Xie, Hairong Bao, Ruowei Yang, Chunyan Wang, Bohao Zheng, Shuang Chang, Xiuxiu Xu, Xiaoling Ni, Tao Suo, Xue Wu, Han Liu, Xiaokun Ma, Houbao Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194824.txt.
Description
Wang and co-authors build in 2026 a blood test model for bile duct cancer based on free DNA fragment patterns. This cancer is usually found late, with poor survival and no good screening tool. Fragment patterns in blood DNA reflect tumor chromatin state and instability.
Shallow genome sequencing of plasma gave three feature types, copy changes, fragment size spread, and promoter fragmentation entropy. A learning model joined them and was trained with cross validation. It beat single features and standard serum markers in validation groups, and split cancer from benign bile disease. Scores tracked disease burden over time in repeat samples, which aids post surgery risk checks.
Catalog record
| CREATOR | Jiwen Wang, Xiaojian Ni, Yuxuan Zheng, Song Wang, Hua Bao, Kun Fan, Sheng Shen, Dongqin Zhu, Qingxin Xie, Hairong Bao, Ruowei Yang, Chunyan Wang, Bohao Zheng, Shuang Chang, Xiuxiu Xu, Xiaoling Ni, Tao Suo, Xue Wu, Han Liu, Xiaokun Ma, Houbao Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |