Toward clinical translation: montmorillonite-enhanced Lactobacillus biofilm alleviates colitis by modulating the gut microbiota–bile acid axis
Zhongyuan Wang, Feng Zhu, Jie Zhang, Kangkang Feng, Waresi Abudourexiti, Song Li, Yanzhe Guo, Mingfei Chen, Zeqian Yu, Lei Zhao, Zhen Guo, Chao Ding, Jianfeng Gong · 2026
Read Toward clinical translation: montmorillonite-enhanced Lactobacillus biofilm alleviates colitis by modulating the gut microbiota–bile acid axis by Zhongyuan Wang, Feng Zhu, Jie Zhang, Kangkang Feng, Waresi Abudourexiti, Song Li, Yanzhe Guo, Mingfei Chen, Zeqian Yu, Lei Zhao, Zhen Guo, Chao Ding, Jianfeng Gong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194550.txt.
Description
Zhongyuan Wang and co-authors built a clay-enhanced probiotic biofilm to treat colitis in 2026. Oral probiotics could help ulcerative colitis, but most bacteria die or fail to stick in the gut, which limits their effect. A common gut-friendly strain was grown as a biofilm on montmorillonite, a clay already used against diarrhea.
In lab tests the clay boosted biofilm growth, survival through gut-like conditions, and sticking to gut lining. In mice with induced colitis, the biofilm beat both free bacteria and a plain mix. It reshaped gut microbes and restored bile acid handling, raising secondary bile acids. Those acids pushed immune cells toward a calming state, which helped settle inflammation.
Catalog record
| CREATOR | Zhongyuan Wang, Feng Zhu, Jie Zhang, Kangkang Feng, Waresi Abudourexiti, Song Li, Yanzhe Guo, Mingfei Chen, Zeqian Yu, Lei Zhao, Zhen Guo, Chao Ding, Jianfeng Gong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |