Integrating multiomics to elucidate the role of chromatin remodeling in glioma and the antitumor mechanisms and therapeutic potential of targeting LMNA
Kun Wang, Feini Xu, Lingjie Zhu, Jiaying Wang, Haibo Li, Xianwen Cao, Xuhan Wang, Da Zong, Yuankun Liu, Junfei Shao · 2026
Read Integrating multiomics to elucidate the role of chromatin remodeling in glioma and the antitumor mechanisms and therapeutic potential of targeting LMNA by Kun Wang, Feini Xu, Lingjie Zhu, Jiaying Wang, Haibo Li, Xianwen Cao, Xuhan Wang, Da Zong, Yuankun Liu, Junfei Shao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194460.txt.
Description
Wang and co-authors mined many data layers to understand chromatin remodeling in glioma, in a study published in 2026, and landed on a structural gene as a drug target. Glioma is a fierce brain cancer with poor outcomes. How DNA is packaged, and repackaged, helps switch the genes that drive it. The team compared tumor and normal brain data from three large cohorts. They pulled out the remodeling genes that differ, then grouped patients by those genes' patterns.
From the grouping they built a risk prediction tool. One target stood out: a gene for a nuclear scaffold protein. Blocking or disturbing it showed anti-tumor promise in their analyses. The work ties packaging machinery to prognosis and therapy at once. It gives glioma research both a score and a suspect.
Catalog record
| CREATOR | Kun Wang, Feini Xu, Lingjie Zhu, Jiaying Wang, Haibo Li, Xianwen Cao, Xuhan Wang, Da Zong, Yuankun Liu, Junfei Shao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |