Decoding atherosclerosis through lactylation: multi-omics integration with experimental validation
Yirong Ma, Qiming Li, Muge Wang, Qiang Wan, Junyu Lai, Jianguang Wu, Shuguang Wu · 2026
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Description
A new chemical mark on proteins, lactylation, ties a cell's fuel use to its gene control, and it may help drive the artery clogging of atherosclerosis. Yirong Ma and six co-authors hunt in 2026 for the genes where that mark matters, blending protein data from stressed vessel cells with public gene data. A dozen learning methods then ranked the candidates.
Four genes survived every filter and checked out in mice, three raised and one lowered in diseased tissue. The four tracked with immune cell presence in the plaques. Computer screening also flagged an existing blood thinner as a possible partner for one of the genes. The authors offer the four as candidate markers and the pairing as a lead to test.
Catalog record
| CREATOR | Yirong Ma, Qiming Li, Muge Wang, Qiang Wan, Junyu Lai, Jianguang Wu, Shuguang Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |