Investigating therapeutic response to netarsudil in glaucoma subjects with the ARHGEF12 risk variant
Anusha Mamidipaka, Isabel Di Rosa, Marine-Ayan Ibrahim Aibo, Fangming Jin, Rebecca Salowe, Roy Lee, Mina Halimitabrizi, Leila Ghaffari, Victoria Addis, Laxmi Moksha, Gui-Shuang Ying, Joan M. O’Brien · 2026
Read Investigating therapeutic response to netarsudil in glaucoma subjects with the ARHGEF12 risk variant by Anusha Mamidipaka, Isabel Di Rosa, Marine-Ayan Ibrahim Aibo, Fangming Jin, Rebecca Salowe, Roy Lee, Mina Halimitabrizi, Leila Ghaffari, Victoria Addis, Laxmi Moksha, Gui-Shuang Ying, Joan M. O’Brien (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194400.txt.
Description
A gene variant may change how a patient answers to a drug, and glaucoma care is testing that idea. Mamidipaka and ten co-authors study ARHGEF12, a gene tied to glaucoma risk in people of African ancestry, and the eye-pressure drug netarsudil, which acts on the same pathway the gene feeds. They compare 1,844 patients by genotype, and track drug response in 66 of them, covering 114 eyes over twelve months.
At the start, all genotype groups looked alike in pressure and severity. On the drug, pressure fell in non-carriers but edged up slightly in carriers, though the gap was far from statistically firm. About a third of eyes in each group hit a twenty percent pressure drop. No other eye measure separated the groups. The authors call the findings exploratory and say bigger studies in untreated patients are needed before gene-guided prescribing.
Catalog record
| CREATOR | Anusha Mamidipaka, Isabel Di Rosa, Marine-Ayan Ibrahim Aibo, Fangming Jin, Rebecca Salowe, Roy Lee, Mina Halimitabrizi, Leila Ghaffari, Victoria Addis, Laxmi Moksha, Gui-Shuang Ying, Joan M. O’Brien |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |