The pathological Huntingtin CAG triplet expansion differentially affects the diagnosis of systemic and organ-specific autoimmune diseases
Moritz Heyd, G. Bernhard Landwehrmeyer, Jan Lewerenz · 2026
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Description
Moritz Heyd and two colleagues ask whether the Huntington's disease mutation changes how often autoimmune diseases occur, in a 2026 study. The mutation expands a repeated stretch in a gene, and signs suggest it stirs the immune system.
Drawing on a large European registry, the team compared over ten thousand mutation carriers with about twenty-five hundred controls. Overall autoimmune rates were alike. The mix differed, though: a thyroid condition was rarer in carriers, while psoriasis was more common. Among carriers, more repeats meant lower autoimmune risk, above all for joint-type diseases. The authors read this as a complex, disease-specific immune effect of the mutation.
Catalog record
| CREATOR | Moritz Heyd, G. Bernhard Landwehrmeyer, Jan Lewerenz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |