Altered regional homogeneity in Parkinson’s disease with mild cognitive impairment: a resting-state fMRI study
Xudong Zhu, Jiaojiao Zhou, Qiancheng Wei, Hong Pu, Yan Chen, Xiaowei Zhu, Bin Li, Shihua Liu · 2026
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Description
Xudong Zhu and co-authors map local brain synchrony changes in Parkinson patients whose thinking has begun to slip, in work from twenty twenty-six. Mild cognitive impairment often shadows Parkinson disease as it progresses. Resting brain scans compare patients with and without that impairment. Healthy controls complete the three-way comparison of local synchrony. A standard thinking test scores cognition for every participant.
Impaired patients show weaker synchrony in two right frontal regions. Synchrony rises instead in cerebellum and temporal areas. Frontal synchrony tracks with better thinking scores in patients. The raised regions track with worse scores by contrast. Two regions separate impaired from unimpaired patients with high accuracy. Such scan markers could flag cognitive decline earlier in Parkinson care.
Catalog record
| CREATOR | Xudong Zhu, Jiaojiao Zhou, Qiancheng Wei, Hong Pu, Yan Chen, Xiaowei Zhu, Bin Li, Shihua Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |