Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system
Tim Kaden, Manuel Allwang, Johannes Stallhofer, Katja Graf, Martin Raasch, Alexander S. Mosig · 2026
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Description
Kaden and co-authors test a bile acid on inflamed gut tissue grown in a chip system. Inflammatory bowel disease has many causes and no curative treatment yet. Past work found that fecal bile acid levels shift with gut microbes and inflammation in this disease.
Lithocholic acid, a secondary bile acid, drops sharply during active disease. Yet it seems to help the gut lining when present. The team applied it in a human intestine-on-chip model with colitis-like inflammation. The acid eased the inflammation in this system, backing its promise as a lead for new gut therapies.
Catalog record
| CREATOR | Tim Kaden, Manuel Allwang, Johannes Stallhofer, Katja Graf, Martin Raasch, Alexander S. Mosig |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |