GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
Sergiy V. Korol, Zhe Jin, Amol K. Bhandage, Hayma Hammoud, Bryndis Birnir · 2026
Read GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells by Sergiy V. Korol, Zhe Jin, Amol K. Bhandage, Hayma Hammoud, Bryndis Birnir (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194042.txt.
Description
Sergiy Korol and four co-authors studied how calming-signal receptors on human immune cells affect calcium inside those cells, in this 2026 paper. The receptors respond to GABA, the brain's main quieting chemical, but they sit on CD4 T cells, a core part of the immune system. When GABA binds them in activated T cells, calcium briefly rises, a signal that helps steer the cell's behavior.
The team activated T cells with an antibody, grew them for three days, and applied four drugs that switch the receptor on. Each drug triggered calcium rises, but the dose needed differed by over a thousand-fold between them, though all counted as high-affinity. They mapped which receptor building blocks the cells express and tested whether blocking potassium channels changed the signal. The work fills in how immune cells hear a signal thought to belong to the brain.
Catalog record
| CREATOR | Sergiy V. Korol, Zhe Jin, Amol K. Bhandage, Hayma Hammoud, Bryndis Birnir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |