Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1
Amit Kumawat · 2026
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Description
Amit Kumawat wrote a 2026 mini review on the cell's main minus-end cargo motor, cytoplasmic dynein-1. This multi-part motor hauls cargo along microtubules toward their minus ends, organizing the cell's interior and powering division. A decade of crystallography and cryo-electron microscopy has photographed its pieces in many poses.
Structures now cover the motor domain, its microtubule grip, the shut-off and open dimer forms, and assemblies with its activator dynactin and cargo adaptors. A partner protein, LIS1, appears in intermediate states. Together these snapshots sketch the motor's stepping cycle and how cofactors switch it on. Yet no unified model connects fuel burning at its several ATP sites to the coordinated motion of all parts. The review argues discrete states and simple kinetics miss the motor's flexibility. Simulation methods may help.
Catalog record
| CREATOR | Amit Kumawat |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |