Somatic mutational profiling identifies aggressive and indolent disease phenotypes in well-differentiated pancreatic neuroendocrine tumors
Leanne M. Brown, Ryan A. Hagenson, Jason M. Sheltzer, John W. Kunstman · 2026
Read Somatic mutational profiling identifies aggressive and indolent disease phenotypes in well-differentiated pancreatic neuroendocrine tumors by Leanne M. Brown, Ryan A. Hagenson, Jason M. Sheltzer, John W. Kunstman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13193833.txt.
Description
Leanne Brown and co-authors profile mutations to sort pancreatic tumors by behavior in a 2026 paper. Well-differentiated pancreatic neuroendocrine tumors are rare and varied, and biomarkers rarely guide their care. Some grow aggressively while others sit indolent for years, and telling them apart early matters.
Using public genomic databases, the team built a large cohort of 434 patients. A modified targeted sequencing approach grouped tumors by their somatic mutations. The mutation patterns separated aggressive from indolent disease types, a step toward matching treatment intensity to the tumor a patient actually has.
Catalog record
| CREATOR | Leanne M. Brown, Ryan A. Hagenson, Jason M. Sheltzer, John W. Kunstman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |