Effect of Branched-Chain Amino Acid Supplementation Alone or Combined With Tryptophan or Methionine on Appetite Control and Related Health Outcomes in Older Adults: Protocol for a Randomized Controlled Trial
Shulin Zhang, Rosilene Ribeiro, David Raubenheimer, Corinne Caillaud, Jian Tan, Samantha Solon-Biet, Peter A Cistulli, Stephen J Simpson · 2026
Read Effect of Branched-Chain Amino Acid Supplementation Alone or Combined With Tryptophan or Methionine on Appetite Control and Related Health Outcomes in Older Adults: Protocol for a Randomized Controlled Trial by Shulin Zhang, Rosilene Ribeiro, David Raubenheimer, Corinne Caillaud, Jian Tan, Samantha Solon-Biet, Peter A Cistulli, Stephen J Simpson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13193670.txt.
Description
Shulin Zhang and co-authors lay out a trial protocol on appetite in older adults in this 2026 paper. Branched-chain amino acids are building blocks found in protein foods and supplements. Mouse work suggested they can drive overeating, depending on which other amino acids come along. No human trial had tested that idea in older people.
The trial enrolled 110 adults aged sixty-five to eighty for four weeks. Groups received no supplement, the amino acids alone, or mixes with tryptophan or methionine. Appetite reports, food intake, body measures, and blood markers are tracked. One hundred participants finished, and results are expected in 2027. The protocol shows how mouse findings get a careful human test.
Catalog record
| CREATOR | Shulin Zhang, Rosilene Ribeiro, David Raubenheimer, Corinne Caillaud, Jian Tan, Samantha Solon-Biet, Peter A Cistulli, Stephen J Simpson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |