Exploring the somatic mutational landscape of ovarian cancer in Estonia
Mikk Tooming, Kadri Rekker, Kadri Toome, Laura Roht, Piret Laidre, Olga Fjodorova, Ustina Šamarina, Sander Pajusalu, Mihkel Ilisson, Pilleriin Peets, Tõnu Jõgi, Karin Klaup, Kristiina Ojamaa, Eva-Maria Niine-Roolaht, Piret Kaarde, Elen Vettus, Jüri Piirsoo, Helen Vahar, Katrin Õunap, Tiina Kahre · 2026
Read Exploring the somatic mutational landscape of ovarian cancer in Estonia by Mikk Tooming, Kadri Rekker, Kadri Toome, Laura Roht, Piret Laidre, Olga Fjodorova, Ustina Šamarina, Sander Pajusalu, Mihkel Ilisson, Pilleriin Peets, Tõnu Jõgi, Karin Klaup, Kristiina Ojamaa, Eva-Maria Niine-Roolaht, Piret Kaarde, Elen Vettus, Jüri Piirsoo, Helen Vahar, Katrin Õunap, Tiina Kahre (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13192237.txt.
Description
Mikk Tooming and a large team map the inherited changes found in ovarian cancer tumors across Estonia, in a study from 2026. The work is the country's first nationwide look of its kind, drawn from routine tumor profiling. It aimed to find changes that drugs can target, and to gauge how germline testing fits in.
A total of 339 tumor samples went through gene sequencing. The mean age at diagnosis was 62.4 years, and high-grade serous cancer made up 82.0 percent of cases. Changes that drugs can act on appeared in 37.5 percent of patients, most often in BRCA1, BRCA2, KRAS, and BRAF. A repair flaw marker showed in 53.2 percent of tested high-grade tumors. Germline tests, done in 41.9 percent, found risk variants in 22.5 percent.
Catalog record
| CREATOR | Mikk Tooming, Kadri Rekker, Kadri Toome, Laura Roht, Piret Laidre, Olga Fjodorova, Ustina Šamarina, Sander Pajusalu, Mihkel Ilisson, Pilleriin Peets, Tõnu Jõgi, Karin Klaup, Kristiina Ojamaa, Eva-Maria Niine-Roolaht, Piret Kaarde, Elen Vettus, Jüri Piirsoo, Helen Vahar, Katrin Õunap, Tiina Kahre |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |