Epigenetic aging markers in the association between frailty and mortality among U.S. adults
May A. Beydoun, Nicole Noren Hooten, Hind A. Beydoun, Michael F. Georgescu, Jack Tsai, Michele K. Evans, Alan B. Zonderman · 2026
Read Epigenetic aging markers in the association between frailty and mortality among U.S. adults by May A. Beydoun, Nicole Noren Hooten, Hind A. Beydoun, Michael F. Georgescu, Jack Tsai, Michele K. Evans, Alan B. Zonderman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13192009.txt.
Description
BackgroundFrailty reflects diminished physiological reserve and increased vulnerability to adverse health outcomes. It has been linked to biological aging, including epigenetic age acceleration (EAA), a DNA methylation–based marker of aging, but the extent to which EAA accounts for the frailty–mortality association remains unclear.MethodsWe analyzed three U.S. cohorts—NHANES (1999–2002), HRS (2016), and HANDLS (2004–2009)—with mortality follow-up through 2019–2022.
Catalog record
| CREATOR | May A. Beydoun, Nicole Noren Hooten, Hind A. Beydoun, Michael F. Georgescu, Jack Tsai, Michele K. Evans, Alan B. Zonderman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |