A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi · 2026
Read A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications by Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191775.txt.
Description
Mohammad Javad Roustaye Gourabi and eight co-authors published a review in twenty twenty-six on beta-lactamase inhibitors, the partner drugs that rescue penicillin-family antibiotics. Bacteria increasingly defeat those antibiotics by making enzymes that chop them apart. Pairing the antibiotic with an inhibitor that disables the enzyme restores the cure.
Since clavulanic acid first proved the idea, the arsenal has grown steadily. The review surveys approved inhibitors and advanced candidates, explaining how each works. It maps which enzyme classes, A through D in the Ambler scheme, each drug can block. It also tracks clinical uses as resistance pushes doctors toward last-resort drugs. The authors frame inhibitor development as central to keeping old antibiotics alive.
Catalog record
| CREATOR | Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |