Investigating the Function of C‑Terminal Tails of Human Tubulin Isotypes in the Motility Regulation of Cytoplasmic Dynein
Jivesh Garg, Julia Lopes Ribeiro, Stefan Wallin, Laleh Alisaraie · 2026
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Description
Garg, Ribeiro, Wallin, and Alisaraie use computer models to study how tail ends of tubulin variants steer a cell motor, in a study from twenty twenty-six. The motor, dynein, hauls cargo along tracks inside cells. Tracks are built from tubulin, which comes in many near-twin forms. Tail differences between forms may tune how the motor grips and moves.
They model six human forms that are common in brain tumors. Three forms changed how the motor's grip domain and stalk flex. Tail swaps also shifted how side links between track strands sit. That shift can change motor speed and run length. Faults in this system link to brain disorders and cancers. Models were needed since pure forms are hard to isolate in the lab.
Catalog record
| CREATOR | Jivesh Garg, Julia Lopes Ribeiro, Stefan Wallin, Laleh Alisaraie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |