Questing for Integrin Targeting Theranostics for Cancer Cell-Selective Molecules
Valentina Giraldi, Tania Pecoraro, Andrea Maurizio, Alessia Milana, Luisa De Cola, Monica Baiula, Daria Giacomini · 2026
Read Questing for Integrin Targeting Theranostics for Cancer Cell-Selective Molecules by Valentina Giraldi, Tania Pecoraro, Andrea Maurizio, Alessia Milana, Luisa De Cola, Monica Baiula, Daria Giacomini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191554.txt.
Description
Valentina Giraldi and co-authors build two molecules meant to find a cancer-related integrin, light it up, and attack the cell it marks. A theranostic agent needs three parts: a warhead, an imaging tag, and a homing piece. Their 2026 paper assembles both candidates around a beta-lactam piece that engages the alpha4beta1 integrin.
One molecule pairs a naphthalimide dye with the classic drug 5-FU. The other uses a BODIPY unit that doubles as light source and weapon under illumination. Binding tests favored the second: it gripped the integrin well while the first did not. Cell adhesion assays on leukemia lines followed. Medicinal chemists get a clear split between a pretty design and a working one.
Catalog record
| CREATOR | Valentina Giraldi, Tania Pecoraro, Andrea Maurizio, Alessia Milana, Luisa De Cola, Monica Baiula, Daria Giacomini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |