Wogonin-Loaded PLGA Sustained-Release Nanomicelle Inhibiting EGFR Pathway for Antitumor Effects in OSCC
Leina Gao, Dixin Cui, Xu Gao, Xiaoling Luan, Huali Gao · 2026
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Description
Leina Gao and co-authors load the flavonoid wogonin into slow-release nanoparticles against mouth cancer, in work from twenty twenty-six. Mouth squamous cancer is the most common head and neck malignancy. Surgery, radiation, and chemo carry moderate gains and harsh side effects. Wogonin kills cancer cells in other models but had not faced mouth cancer. Its poor water solubility also limits direct medical use.
Polymer nanoparticles carry wogonin and release it in a sustained way. Dish tests show strong cuts in cancer cell growth and movement. Cell death rates rise under the loaded particles as well. Network and gene checks point to a growth receptor path as the target. Blood and organ checks confirm the particles are well tolerated. The study gives first systematic proof for wogonin in this cancer. Preclinical development gains a concrete starting formulation.
Catalog record
| CREATOR | Leina Gao, Dixin Cui, Xu Gao, Xiaoling Luan, Huali Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |