Cancer-specific bivalent promoters featuring low-level H3K27me3 signals favor active transcription and govern the cancer cell state transition
Fan Yang, Guanlan Fan, Jing Cao, Qiuyan Zhao, Kexiu Guo, Min Liu, Xin Yin, Hongying Zong, Feng Li, Fubing Wang, Jie Xiong · 2025
Read Cancer-specific bivalent promoters featuring low-level H3K27me3 signals favor active transcription and govern the cancer cell state transition by Fan Yang, Guanlan Fan, Jing Cao, Qiuyan Zhao, Kexiu Guo, Min Liu, Xin Yin, Hongying Zong, Feng Li, Fubing Wang, Jie Xiong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191472.txt.
Description
Fan Yang and co-authors pick out in 2025 a class of gene start sites in cancer that wear both wake and hush marks yet still sing loud. In stem cells such twin marks hold genes low and poised. In cancer they seem to drive growth plans, a clash the team sets out to crack.
The cancer set wears thin, nar row hush coats and rich wake coats, which lets key stem genes stay on. One such gene heads the case list. Twin marks form as state shifts lay the hush coat down by set bind steps. Break the twin state and wake marks soar, clones stall, and tumors fail.
Catalog record
| CREATOR | Fan Yang, Guanlan Fan, Jing Cao, Qiuyan Zhao, Kexiu Guo, Min Liu, Xin Yin, Hongying Zong, Feng Li, Fubing Wang, Jie Xiong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |