Cytosolic localization of MBL-1/Muscleblind may be required for ectopic neurite outgrowth in a sensitized background in C. elegans
Ho Ming Terence Lee, Chaogu Zheng · 2026
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Description
Ho Lee and Chaogu Zheng test where a splicing protein must sit in the cell to grow extra nerve branches in worms, in a 2026 study. The protein, Muscleblind, works in the nucleus on RNA splicing and in the cell body on RNA stability. Its worm form comes in long and short versions carrying two, one, or no copies of a tag that sends it to the nucleus.
The team built worms with each version. The two tag protein stayed locked in the nucleus and could not drive extra branch growth in a sensitized strain. One tag and no tag versions spread to both compartments. Cell body presence, the authors infer, is the key.
Catalog record
| CREATOR | Ho Ming Terence Lee, Chaogu Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |