A genome-wide genetic screen identifies a novel kDNA replication protein in trypanosomes
Migla Miskinyte, Clirim Jetishi, Ana Kalichava, Alasdair Ivens, Martin Waterfall, Matthew K Gould, Lucy Glover, David Horn, Torsten Ochsenreiter, Achim Schnaufer · 2026
Read A genome-wide genetic screen identifies a novel kDNA replication protein in trypanosomes by Migla Miskinyte, Clirim Jetishi, Ana Kalichava, Alasdair Ivens, Martin Waterfall, Matthew K Gould, Lucy Glover, David Horn, Torsten Ochsenreiter, Achim Schnaufer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191291.txt.
Description
The parasite that causes sleeping sickness keeps its mitochondrial DNA in a woven disk called the kinetoplast, copied by an estimated three hundred proteins, most still unknown. Migla Miskinyte and co-authors built a genome-wide screen in 2026 to find the missing crew. Of their twenty top-ranked genes, six were already known maintenance factors, which validated the hunt.
They chased one unknown hit and proved its beat. Remove the protein and the kinetoplast DNA drains away, while the machinery that partitions it stays intact, marking the protein as a replication factor. A rescue experiment nailed the specificity. The authors hand the field a ranked list of further suspects.
Catalog record
| CREATOR | Migla Miskinyte, Clirim Jetishi, Ana Kalichava, Alasdair Ivens, Martin Waterfall, Matthew K Gould, Lucy Glover, David Horn, Torsten Ochsenreiter, Achim Schnaufer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |