Disruption of the structural maintenance of chromosomes 5/6 complex enables tumor mutagenesis
Thi Tran, Jiayi Fan, Xiaolan Zhao, Abby M Green · 2026
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Description
Thi Tran and co-authors study a chromosome care complex in cancer in a 2026 paper. The SMC5/6 complex protects genome stability and is essential for development. Inherited faults in it cause instability syndromes.
What happens when tumors acquire faults in the same complex was unknown. Three databases with thousands of tumors were searched. Harmful small variants, but not copy losses, tracked higher mutation counts. Much of that extra mutation came from a faulty polymerase and repair defects. Readers learn how a genome guardian, once broken, can speed the mutation load that drives cancer change.
Catalog record
| CREATOR | Thi Tran, Jiayi Fan, Xiaolan Zhao, Abby M Green |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |