Sustained β-catenin activation via GSK3 inhibition promotes direct fibroblast-to-cardiomyocyte reprogramming
Xinghua Wang, Iqra Anwar, Richard E Pratt, Victor J Dzau, Conrad P Hodgkinson · 2026
Read Sustained β-catenin activation via GSK3 inhibition promotes direct fibroblast-to-cardiomyocyte reprogramming by Xinghua Wang, Iqra Anwar, Richard E Pratt, Victor J Dzau, Conrad P Hodgkinson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191247.txt.
Description
Xinghua Wang, Iqra Anwar, Richard Pratt, Victor Dzau, and Conrad Hodgkinson turn scar cells into heart muscle by holding one signal on, in a study from two thousand twenty-six. Stem cell routes need that signal on, then off, to make heart cells. Direct conversion was probed for the same logic.
Blocking one brake enzyme early kept the signal on, with no later off-step needed. Yield rose and the new cells matured better, as calcium maps showed. Gene reads grew richer in muscle terms, and side paths stayed quiet. The split from the stem route is stark. Readers get a timing rule for building heart cells direct.
Catalog record
| CREATOR | Xinghua Wang, Iqra Anwar, Richard E Pratt, Victor J Dzau, Conrad P Hodgkinson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |