Graded ankle instability induces early osteoarthritic changes in a rat model
Kenji Murata, Sora Kawabata, Chiharu Takasu, Nihei Kota, Naoki Shimada, Naohiko Kanemura · 2026
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Description
Murata and co-authors watch ankle arthritis begin in rats with loosened ankle ligaments in this 2026 study. Sprains leave ankles wobbly, and wobble is suspected of wearing cartilage down. The team cut one or both of two ligaments to create graded looseness, then checked joints and walking over eight weeks.
Looseness grew with each added cut, and cartilage damage scores rose in step. Gene scans of the cartilage found 245 changed genes, many tied to immune cells that respond to inflammation. Two genes stood out as possible bridges between mechanical stress and inflammation. The graded model lets researchers test how instability dose drives early joint decay.
Catalog record
| CREATOR | Kenji Murata, Sora Kawabata, Chiharu Takasu, Nihei Kota, Naoki Shimada, Naohiko Kanemura |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |