Technical implementation for african pharmacogenetic studies on CYP2D6 from archived breast cancer formalin fixed paraffin-embedded (FFPE) tissues
Keneuoe Cecilia Nthontho, Leabaneng Tawe, Nduta Mugo, Rorisang Mabaka, Gianmarco Contino, Andrew Khulekani Ndlovu, Daniel Paul Morse, Giacomo Maria Paganotti · 2026
Read Technical implementation for african pharmacogenetic studies on CYP2D6 from archived breast cancer formalin fixed paraffin-embedded (FFPE) tissues by Keneuoe Cecilia Nthontho, Leabaneng Tawe, Nduta Mugo, Rorisang Mabaka, Gianmarco Contino, Andrew Khulekani Ndlovu, Daniel Paul Morse, Giacomo Maria Paganotti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191098.txt.
Description
Keneuoe Nthontho and co-authors set out a lab method for African gene studies in 2026. The gene CYP2D6 shapes how many drugs are processed in the body. Stored breast cancer tissue blocks offer a rich source for such studies in Africa. Yet the fixing process breaks DNA into small pieces, which makes testing hard.
The team built test protocols tuned for DNA from these stored blocks. Their nested methods target key variants of the gene that matter for drug response. Archived blocks are cheap and widely kept in lower income settings. A working method on this material opens gene guided care studies to many more patients and labs.
Catalog record
| CREATOR | Keneuoe Cecilia Nthontho, Leabaneng Tawe, Nduta Mugo, Rorisang Mabaka, Gianmarco Contino, Andrew Khulekani Ndlovu, Daniel Paul Morse, Giacomo Maria Paganotti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |