Gender-Specific Behavior Reductions in Spontaneous Locomotive and Rearing in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy: A Pilot Study
Serena Jiyeon Kim, Kevin Cao, Patrick M Dougherty, Kathleen E McDonough, Saba Javed · 2026
Read Gender-Specific Behavior Reductions in Spontaneous Locomotive and Rearing in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy: A Pilot Study by Serena Jiyeon Kim, Kevin Cao, Patrick M Dougherty, Kathleen E McDonough, Saba Javed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13191044.txt.
Description
Serena Kim and co-authors tracked everyday movement in rats given a chemotherapy drug known to damage nerves, in a pilot study published in 2026. Open field video recorded distance traveled, rearing, and time in center or edge zones before and after dosing. The aim was a fuller picture than pain tests alone give.
Treated rats moved less and reared less overall, which mirrors patient complaints. Split by sex, males lost both distance and rearing, while females lost distance but kept rearing. Anxiety like behavior showed no steady change. The authors say spontaneous activity is a fair, patient relevant yardstick for nerve damage and for testing future treatments.
Catalog record
| CREATOR | Serena Jiyeon Kim, Kevin Cao, Patrick M Dougherty, Kathleen E McDonough, Saba Javed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |