Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients
Thomas E van der Schalk, Matilda Berkell, An Hottebeekx, Leen Timbermont, David E Tabor, Christine Lammens, Claudia Recanatini, Alexey Ruzin, Antonio DiGiandomenico, Hasan Jafri, Jean Chastre, Mark T Esser, Bruno François, Marc J M Bonten, Herman Goossens, Jan A J W Kluytmans, Antonio Oliver, Youri · 2026
Read Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients by Thomas E van der Schalk, Matilda Berkell, An Hottebeekx, Leen Timbermont, David E Tabor, Christine Lammens, Claudia Recanatini, Alexey Ruzin, Antonio DiGiandomenico, Hasan Jafri, Jean Chastre, Mark T Esser, Bruno François, Marc J M Bonten, Herman Goossens, Jan A J W Kluytmans, Antonio Oliver, Youri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13190808.txt.
Description
A European study team led by Thomas E van der Schalk reports a two thousand twenty-six study of how a hospital superbug adapts under antibiotics in intensive care patients. Pseudomonas aeruginosa evolves fast and resists many drugs. Resistance to one drug sometimes reopens sensitivity to another.
Longitudinal samples from ventilated patients were compared with lab strains evolved under single drugs. Certain antibiotics drove resistance paired with such collateral sensitivity. Mutational paths differed by drug pressure. The findings suggest treatment sequences could exploit these trade-offs, a strategy intensive care rarely plans today.
Catalog record
| CREATOR | Thomas E van der Schalk, Matilda Berkell, An Hottebeekx, Leen Timbermont, David E Tabor, Christine Lammens, Claudia Recanatini, Alexey Ruzin, Antonio DiGiandomenico, Hasan Jafri, Jean Chastre, Mark T Esser, Bruno François, Marc J M Bonten, Herman Goossens, Jan A J W Kluytmans, Antonio Oliver, Youri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |