Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis
Anna C. Lilly, Valerii A. Pavlov, Shabnam Pirestani, Adam Chatoff, Kathy Q. Cai, Edna Cukierman, Nathaniel W. Snyder, Igor Astsaturov, Erica A. Golemis · 2026
Read Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis by Anna C. Lilly, Valerii A. Pavlov, Shabnam Pirestani, Adam Chatoff, Kathy Q. Cai, Edna Cukierman, Nathaniel W. Snyder, Igor Astsaturov, Erica A. Golemis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13190320.txt.
Description
Levels of pancreatic ductal adenocarcinoma (PDAC) are increasing, with epidemiological studies nominating obesity, altered cholesterol metabolism, and elevated lipids as risk factors. In prior studies, we determined that elevated expression of sterol regulatory element binding protein 2 (SREBP2), a transcription factor directing lipid biosynthesis, promoted epithelial-mesenchymal transition and aggressive tumorigenesis in the KPC (LSL-KrasG12D;Trp53f/f;Pdx1-Cre) mouse model of PDAC.
Catalog record
| CREATOR | Anna C. Lilly, Valerii A. Pavlov, Shabnam Pirestani, Adam Chatoff, Kathy Q. Cai, Edna Cukierman, Nathaniel W. Snyder, Igor Astsaturov, Erica A. Golemis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |