The role of inflammation in the immune evasion of KRas
E. Jane Homan, Robert D. Bremel · 2026
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Description
Jane Homan and Robert Bremel argue that inflammation helps KRas tumors hide from the immune system. KRas faults drive over a quarter of all tumors, most at two hot spots in the gene. Vaccines can raise immune replies to these tumors, yet drug-free immune control has mostly failed. The missing piece, they propose, is an enzyme that leaks during inflammation.
That enzyme, cathepsin B, spills from cell waste sacs when tissue is inflamed. At the higher acidity balance of the cell body, it gains a cutting mode. The authors predict its cuts shred the mutant KRas bits that immune cells would flag. They also weigh links with pancreas enzymes and inflammasome parts. A scheme joins the claims into one model of escape.
Catalog record
| CREATOR | E. Jane Homan, Robert D. Bremel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |