Deviations from the inverse relationship between tumor and normal tissue dose and RBE in fast neutron data are compatible with the presence of hypoxia, with possible applications to hypo-fractionated proton therapy
Bleddyn Jones · 2026
Read Deviations from the inverse relationship between tumor and normal tissue dose and RBE in fast neutron data are compatible with the presence of hypoxia, with possible applications to hypo-fractionated proton therapy by Bleddyn Jones (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13189794.txt.
Description
Bleddyn Jones models why fast neutron data from Hammersmith break the usual inverse link between dose and relative biological effectiveness, or RBE. The old data had ascribed the break to low-oxygen, or hypoxic, cells. Jones builds a model with oxic and hypoxic compartments, using the linear-quadratic form and sensitivity that rises with linear energy transfer.
The model fits three unlike cases well: normal skin, a mouse mammary cancer, and an Ehrlich ascites cancer. As dose rises, the overall RBE drifts from the oxic curve toward the higher hypoxic curve, set mainly by the starting hypoxic share. Like patterns arise for protons in the model, but not from dose rate effects alone.
Catalog record
| CREATOR | Bleddyn Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |