Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy
Zhifang Li, Shengheng Xu, Xuelian Jiang, Xue Yang, Shaoheng Cui, Yuchao Lu, Xiao Duan, Jinping Zheng · 2026
Read Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy by Zhifang Li, Shengheng Xu, Xuelian Jiang, Xue Yang, Shaoheng Cui, Yuchao Lu, Xiao Duan, Jinping Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13189193.txt.
Description
Zhifang Li and seven co-authors published a 2026 drug delivery study on a redesigned form of chlorambucil, a proven drug for blood cancers. The drug dissolves poorly in water, breaks down fast in body fluids, and harms healthy tissue at high doses. Standard nanocarriers load little drug and are complex to make.
The team chemically linked the drug to tromethamine, a common safe excipient, creating a prodrug that assembles into nano micelles on its own. Tests covered particle traits, stability in water, and killing of lymphoma cells in dishes. The micelles entered cells well and triggered cell death. In a mouse model of the cancer, the prodrug micelles fought tumors better than the plain drug. The design promises higher loading with simpler production.
Catalog record
| CREATOR | Zhifang Li, Shengheng Xu, Xuelian Jiang, Xue Yang, Shaoheng Cui, Yuchao Lu, Xiao Duan, Jinping Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |