Pyroptosis, A Double-Edged Sword in Respiratory Diseases: A Narrative Review
Chen Yu, Caijun Dai, Lujian Zhu · 2026
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Description
Chen Yu, Caijun Dai, and Lujian Zhu wrote a review dated 2026 on a fiery form of cell death called pyroptosis. In this process, danger signals trigger enzymes that cut a protein named gasdermin D. The cut pieces punch pores in the cell wall, so the cell swells and bursts, spilling inflammatory contents.
That burst helps fight germs, but too much of it damages tissue. The review traces the steps of the process and its control networks. It then walks through lung conditions where the process plays a role: infections, acute lung injury, asthma, chronic obstructive disease, scarring of the lungs, and lung cancer. Drugs that target this pathway are also reviewed as possible future treatments.
Catalog record
| CREATOR | Chen Yu, Caijun Dai, Lujian Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |