Folate-mediated inflammatory microenvironment-responsive nanocarriers for the delivery of Moringa A to target NLRP3 for the treatment of viral pneumonia
Taoyuan Zeng, Jiayu Li, Wenyi Yao, Xu Cheng, Dandan Yang, Chunmei Lv, Yongai Xiong · 2026
Read Folate-mediated inflammatory microenvironment-responsive nanocarriers for the delivery of Moringa A to target NLRP3 for the treatment of viral pneumonia by Taoyuan Zeng, Jiayu Li, Wenyi Yao, Xu Cheng, Dandan Yang, Chunmei Lv, Yongai Xiong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13188134.txt.
Description
Taoyuan Zeng and co-authors built a targeted drug carrier in 2026 for treating viral pneumonia in mice. Severe lung infection can trigger a storm of immune signals, and a cell alarm system called NLRP3 is a key driver of that storm and of lung damage.
The team packed a plant compound into tiny carriers coated with folic acid, which homes to inflamed tissue. In infected cells, the carriers lowered the alarm system's parts and the signals that drive cell death by bursting. Lab checks confirmed the compound blocks the alarm directly. In mice, the treatment lowered lung swelling and damage, and shifted immune cells toward a calmer state.
Catalog record
| CREATOR | Taoyuan Zeng, Jiayu Li, Wenyi Yao, Xu Cheng, Dandan Yang, Chunmei Lv, Yongai Xiong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |