Central nervous system adaptation mechanism of obesity induced by high-fat high-sucrose diet: Differences in brain function between obese and obese resistant rats based on fMRI
Qi Fang, Shantong Zhao, Qiutong Lin, Xiaoyun Zhu, Changhao Zheng, Yunlong Wang, Tao Lu, Lili Zhu · 2026
Read Central nervous system adaptation mechanism of obesity induced by high-fat high-sucrose diet: Differences in brain function between obese and obese resistant rats based on fMRI by Qi Fang, Shantong Zhao, Qiutong Lin, Xiaoyun Zhu, Changhao Zheng, Yunlong Wang, Tao Lu, Lili Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13188111.txt.
Description
Qi Fang and seven co-authors compared brain activity in rats that grow fat on rich food and rats that resist in a 2026 paper. A high-fat, high-sugar diet makes some animals obese and leaves others lean, for reasons that may sit in the brain. The team fed forty male rats and split the rich-diet group by weight after eight weeks.
The obese rats kept overeating, with worse blood fats, glucose tolerance, and heavier organs. Brain scans showed quieter activity in the hindbrain and livelier activity in a memory-linked cortex in the obese group, and the two regions' activity moved in opposite directions. The authors read this as rewiring of a hindbrain-cortex circuit under long rich feeding.
Catalog record
| CREATOR | Qi Fang, Shantong Zhao, Qiutong Lin, Xiaoyun Zhu, Changhao Zheng, Yunlong Wang, Tao Lu, Lili Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |