Dynamic sumoylation is essential in yeast for suppressing stress-induced gene expression in non-stress conditions
Marjan Moallem, J Bryan McNeil, Benjamin G Bergey, Emanuel Rosonina · 2026
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Description
Marjan Moallem, Bryan McNeil, Benjamin Bergey, and Emanuel Rosonina investigate how the SUMO protein-tagging system shapes yeast responses to stress. Heat shock triggers the environmental stress response, a broad gene-expression program, alongside a global rise in SUMO attachment. The team asked which direction the causality runs.
A mutant unable to remove SUMO normally showed stress-like gene expression with no stress present, driven by two stress regulators. A mutant with reduced SUMO attachment showed similar effects. Both too much and too little tagging disrupted the cycle. The authors conclude that proper SUMO cycling, not the absolute amount, keeps stress genes off in calm conditions. The finding adds a regulatory layer to stress signaling.
Catalog record
| CREATOR | Marjan Moallem, J Bryan McNeil, Benjamin G Bergey, Emanuel Rosonina |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |