The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats
Sandra Ollivaud, Daniele Novarina, Elizabeth C Riquelme Barrientos, Hinke G Kazemier, Suzan Gonera, Maxime Kislanski, Liesbeth M Veenhoff, Michael Chang · 2026
Read The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats by Sandra Ollivaud, Daniele Novarina, Elizabeth C Riquelme Barrientos, Hinke G Kazemier, Suzan Gonera, Maxime Kislanski, Liesbeth M Veenhoff, Michael Chang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13187838.txt.
Description
Sandra Ollivaud and co-authors study how the nuclear pore complex guards the steadiness of short repeated DNA stretches. Such repeats, when they swell, drive several nerve diseases. Pore complexes ferry cargo in and out of the nucleus, and hard-to-fix DNA is known to move toward them.
In their 2026 study, disease-linked repeats of many kinds shift to the pore, a move that leans on the basket protein Nup1 alone. Blocking the move raises the rate at which repeats shrink, though growth stays put. A second basket loss tells apart: it harms damage defense without touching the move. The pore's repeat watch and its other genome duties can thus be pried apart.
Catalog record
| CREATOR | Sandra Ollivaud, Daniele Novarina, Elizabeth C Riquelme Barrientos, Hinke G Kazemier, Suzan Gonera, Maxime Kislanski, Liesbeth M Veenhoff, Michael Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |