A Multi-Omics Study of Comorbid Mechanisms Between Depression and Inflammatory Dermatoses Identifies FADS1 and TMEM258 as Therapeutic Targets
Yibo Feng, Xiang Chen, Xinlan Qiu, Runlin Zhang, Zhiyu Cui, Xiaohui Mo, Qiang Ju · 2026
Read A Multi-Omics Study of Comorbid Mechanisms Between Depression and Inflammatory Dermatoses Identifies FADS1 and TMEM258 as Therapeutic Targets by Yibo Feng, Xiang Chen, Xinlan Qiu, Runlin Zhang, Zhiyu Cui, Xiaohui Mo, Qiang Ju (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13186223.txt.
Description
Yibo Feng and six co-authors use gene and multi layer data to probe why depression and inflammatory skin diseases often occur together. People with long term skin inflammation face higher rates of mental illness, likely through shared biology. The team set out to test causal links and find the genes that mediate them.
Gene based causal tests suggested that a tendency to depression raises the risk of psoriasis. One skin condition, atopic dermatitis, in turn raised the risk of depression. Fourteen genes were tied to the overlap, with immune paths in the lead. Two genes stood out as drug targets after checks on expression and drug potential. The work maps a two way street between skin and mind.
Catalog record
| CREATOR | Yibo Feng, Xiang Chen, Xinlan Qiu, Runlin Zhang, Zhiyu Cui, Xiaohui Mo, Qiang Ju |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |