Efficacy and Safety of Fimasartan/Indapamide Combination Therapy versus Fimasartan Monotherapy in Patients with Essential Hypertension Inadequately Responding to Fimasartan 30 mg (FINEDUO): A Randomized, Double-Blind, Multicenter, Phase III Study
Jong-Chan Youn, So-Young Lee, Cheol Woong Yu, Ki-Chul Sung, Jinho Shin, Ju Hyeon Oh, Jin Oh Na, Dae-Hee Kim, Eun Joo Cho, Hyuck-Jun Yoon, Chan Joo Lee, Han Cheol Lee, Hae-Young Lee, Il Suk Sohn, Kyu-Sun Lee, Doo Il Kim, Woong Gil Choi, Wook-Jin Chung, Eun Mi Lee, Seung-Hyuk Choi, Seonghoon Choi, Tae · 2026
Read Efficacy and Safety of Fimasartan/Indapamide Combination Therapy versus Fimasartan Monotherapy in Patients with Essential Hypertension Inadequately Responding to Fimasartan 30 mg (FINEDUO): A Randomized, Double-Blind, Multicenter, Phase III Study by Jong-Chan Youn, So-Young Lee, Cheol Woong Yu, Ki-Chul Sung, Jinho Shin, Ju Hyeon Oh, Jin Oh Na, Dae-Hee Kim, Eun Joo Cho, Hyuck-Jun Yoon, Chan Joo Lee, Han Cheol Lee, Hae-Young Lee, Il Suk Sohn, Kyu-Sun Lee, Doo Il Kim, Woong Gil Choi, Wook-Jin Chung, Eun Mi Lee, Seung-Hyuk Choi, Seonghoon Choi, Tae (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13186222.txt.
Description
Jong-Chan Youn and a large team ran a phase three trial in 2026 on a two-drug pill for high blood pressure. Many patients need more than one drug to reach safe levels. The trial enrolled patients whose pressure stayed high on a single drug, called fimasartan, after a run-in period.
Patients were split at random between the single drug and the same drug plus a second one that removes fluid. After eight weeks, the combined pill lowered the top pressure reading far more than the single drug. Control rates were also better, and side effects were much the same in both groups, including among older patients. The authors see the pairing as a useful option.
Catalog record
| CREATOR | Jong-Chan Youn, So-Young Lee, Cheol Woong Yu, Ki-Chul Sung, Jinho Shin, Ju Hyeon Oh, Jin Oh Na, Dae-Hee Kim, Eun Joo Cho, Hyuck-Jun Yoon, Chan Joo Lee, Han Cheol Lee, Hae-Young Lee, Il Suk Sohn, Kyu-Sun Lee, Doo Il Kim, Woong Gil Choi, Wook-Jin Chung, Eun Mi Lee, Seung-Hyuk Choi, Seonghoon Choi, Tae |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |