Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders
Li Li, Qi Han, Hao-Lei Bai, Qin Xiao, Xie He, Jia-Fei Chen, Zhi-Ming Zhen, Xue-Qin Luo, Yuan-Jing Zhang, Min-Min Lu, Xiao Wang, Shi-Yin Li, Jia-Xiang Xiong, Yun Wang, Zhi-An Hu, Xiao-Long Zhang, Yong Liu, Chao He · 2026
Read Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders by Li Li, Qi Han, Hao-Lei Bai, Qin Xiao, Xie He, Jia-Fei Chen, Zhi-Ming Zhen, Xue-Qin Luo, Yuan-Jing Zhang, Min-Min Lu, Xiao Wang, Shi-Yin Li, Jia-Xiang Xiong, Yun Wang, Zhi-An Hu, Xiao-Long Zhang, Yong Liu, Chao He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13186025.txt.
Description
Li Li and colleagues studied how nerve pain after shingles wrecks sleep, and which brain hub sits at the center. Pain and poor sleep feed each other in a cycle that worsens both. The team focused on shingles-related nerve pain, a severe form of the condition. They paired sleep lab tests with brain measures.
Thirty-seven patients with this pain took part, none with prior long-term insomnia. Their pain levels ran high, and worse pain went with worse insomnia scores. Overnight sleep tests showed far more awakenings than in healthy adults. Time spent awake after falling asleep also rose. The authors point to a relay area deep in the brain, the mediodorsal thalamus, as wrongly rewired in this state. That rewiring, they argue, is a core driver of the pain-sleep cycle.
Catalog record
| CREATOR | Li Li, Qi Han, Hao-Lei Bai, Qin Xiao, Xie He, Jia-Fei Chen, Zhi-Ming Zhen, Xue-Qin Luo, Yuan-Jing Zhang, Min-Min Lu, Xiao Wang, Shi-Yin Li, Jia-Xiang Xiong, Yun Wang, Zhi-An Hu, Xiao-Long Zhang, Yong Liu, Chao He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |