Circadian clock and cancer
Zhi-Hao Wei, Zi-Rui Dong, An-Shu Li, Qing-Yi Li, Jian Shi, Ke-Shan Wang, Xiao-Ping Zhang · 2026
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Description
Zhi-Hao Wei and six co-authors review the circadian clock and cancer, from tumor initiation to treatment response. Circadian rhythms govern the sleep-wake cycle, hormone secretion, and metabolism, synchronized mainly by the light-dark cycle. Their 2026 review sums up the evidence that disruption or reprogramming of these rhythms is closely tied to cancer. At the molecular level, dysregulation of core clock genes disturbs cell rhythms, freeing proliferation, impairing DNA repair, altering metabolism, and disrupting immune responses.
Treatment paths receive the same close reading: behavioral interventions, drugs that modulate clock genes, and gene-editing techniques. Each path aims to reset the clock as a therapy in its own right. The team frames clock-based care as a novel arm for cancer management, to sit beside surgery, drugs, and radiation, not to replace them. Clinical applications are highlighted throughout the review.
Catalog record
| CREATOR | Zhi-Hao Wei, Zi-Rui Dong, An-Shu Li, Qing-Yi Li, Jian Shi, Ke-Shan Wang, Xiao-Ping Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 151 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |